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Even a 2°C drop in the core body temperature can cause hypothermia. At this point, the effects of cold on the brain are most apparent. "At 18°C, we'll have a massive leak in our blood-brain barrier, and the brain is not protected anymore from the normal junk we produce," Gracheva said. The resulting flood of toxins through the hole-ridden ... sign in | Science News AAAS | Login. Welcome to the Science Content Tracking System. This is the manuscript management site for authors, reviewers and advisors of the Science journals. Information for authors... Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing Scholastic Science World | The Current Science Magazine for Grades 6-10 Authors and reviewers must have an account to sign into our Content Tracking System (CTS) at https://cts.sciencemag.org. If you do not have an account, you will need to create one by following the prompts on the welcome page. Science | AAAS What is Nature+? 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